naloxone

noun

nal·​ox·​one na-ˈläk-ˌsōn How to pronounce naloxone (audio)
: a synthetic potent antagonist of narcotic drugs (such as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence.

Examples of naloxone in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
But undoubtedly, naloxone has been a game-changer in saving lives from overdose. Jackie Siegel, The Orlando Sentinel, 6 June 2025 Individuals who come to after getting naloxone should still receive immediate medical care. Katia Hetter, CNN Money, 5 June 2025 Family Guidance Centers’ other van delivers naloxone, also known as Narcan, which can revive a person suffering an opioid overdose, Vlasaty said. Mike Nolan, Chicago Tribune, 30 May 2025 Narcan, the nasal spray version of naloxone, has received F.D.A. approval to be sold over the counter and should be widely available by late summer. Jan Hoffman, New York Times, 15 May 2025 See All Example Sentences for naloxone

Word History

Etymology

N-allyl + hydroxy- + -one

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of naloxone was in 1964

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Cite this Entry

“Naloxone.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/naloxone. Accessed 10 Jun. 2025.

Medical Definition

naloxone

noun
: a potent synthetic antagonist of narcotic drugs (as morphine and fentanyl) that is administered especially in the form of its hydrochloride C19H21NO4·HCl

Note: Naloxone is administered by injection or as a nasal spray to reverse the effects of opioids and especially in the emergency treatment of opioid overdose. It is also administered in combination with buprenorphine in the form of a dissolvable tablet placed under the tongue or a film placed inside the cheek to treat opioid dependence. Trademarks for preparations containing naloxone include Bunavail, Evzio, Narcan, Suboxone, and Zubsolv.

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