metastasis

noun

me·​tas·​ta·​sis mə-ˈta-stə-səs How to pronounce metastasis (audio)
plural metastases mə-ˈta-stə-ˌsēz How to pronounce metastasis (audio)
1
a
: change of position, state, or form
b
: the spread of a disease-producing agency (such as cancer cells) from the initial or primary site of disease to another part of the body
metastasis of breast cancer to boneMedical Physics
also : the process by which such spreading occurs
2
: a secondary malignant (see malignant sense 1) tumor resulting from metastasis
metastatic adjective
metastatically adverb

Examples of metastasis in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Imaging studies: Computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, or positron emission tomography (PET) scans can help detect cancerous tumors and metastasis. Carrie Madormo, Health, 18 July 2025 Wu, a neuroscientist, had a nearly 40-year career including nearly two decades at Northwestern, according to the complaint, which said her lab researched tumor development and metastasis, in addition to efforts to fight neurodegenerative diseases. Kimmy Yam, NBC news, 12 July 2025 Lung metastasis refers to any cancer that begins in one part of the body and spreads to another – in the case of McMahon, head and neck metastatic cancer, the report reveals. Anna Kaufman, USA Today, 11 July 2025 This is called secondary liver cancer or liver metastases. Tim Ryan, MSNBC Newsweek, 6 July 2025 See All Example Sentences for metastasis

Word History

Etymology

New Latin, from Late Latin, transition, from Greek, from methistanai to change, from meta- + histanai to set — more at stand

First Known Use

1663, in the meaning defined at sense 1a

Time Traveler
The first known use of metastasis was in 1663

Browse Nearby Words

Cite this Entry

“Metastasis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/metastasis. Accessed 30 Jul. 2025.

Kids Definition

metastasis

noun
me·​tas·​ta·​sis mə-ˈtas-tə-səs How to pronounce metastasis (audio)
plural metastases -ˌsēz How to pronounce metastasis (audio)
1
: the spread of something that produces disease (as cancer cells) from the original location of disease to another part of the body
2
: a growth of a malignant tumor in another part of the body resulting from metastasis

Medical Definition

metastasis

noun
me·​tas·​ta·​sis mə-ˈtas-tə-səs How to pronounce metastasis (audio)
plural metastases -ˌsēz How to pronounce metastasis (audio)
1
a
: change of position, state, or form
b
: the spread of a disease-producing agent (as cancer cells or bacteria) or disease from the initial or primary site of disease to another part of the body
The overwhelming concern about prostate cancer is its potential for metastasis—for cells to escape the gland and take root in lymph nodes, bones, lungs, skin, or other tissue.Tom Alexander, Fortune
also : the process by which such spreading occurs
2
: a secondary malignant tumor resulting from metastasis
… radiation has no known effect on distant metastases from breast cancer …David Plotkin, The Atlantic Monthly

More from Merriam-Webster on metastasis

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